“We want to create effective treatments”

Antibiotics A New replacement in the fight against Superbacteria, According to a study published in the magazine on Tuesday Trends of biotechnology And led by researchers at the University of Pennsylvania (USA). The group, which has done their work in laboratory tests and animal samples, found the “unusual” evidence of the “unusual” proof of the “stressful requirement of” stressful requirement of anti -bacteria in these waterfalls.

In particular, synthetic peptides were developed, derived from natural compounds found in the Odoronna Andersoni frog. These molecules are a “Faithful ability” in the fight against bacterial infections Gram-negative, treatment is always difficult. Waterfalls, such as frogs, use powerful antimicrobial peptides as the first line of protection against infections, describing a report.

Inspired by these natural molecules, researchers have developed artificial versions, especially Gram-negative pathogens. By changing the key features of molecules to join the bacterial membranes (hydropropicity), they were able to create equipment by changing key features such as their electricity charges Compounds that aggressively attack harmful bacteriaWithout affecting healthy human cells or intestinal microbiota.

Used “It is allowed to create artificial peptides with a specific approach to harmful pathogens, which This allows you to reduce unnecessary effects“Researcher Angela Caesaro pointed out. For her, this method also reduces the risk of resistance” is the most sophisticated alternative to conventional antibiotics. “

These synthetic peptides were useful in laboratory tests and premature animal samples, which received the results of established antibiotics such as polymatic B and levofloxacin. Besides, Initial findings suggest that these peptides do not seem to trigger antibiotic resistance“Especially stimulating advantage” because regular drugs lose effectiveness against bacteria that quickly transform.

As for the usual wide spectrum antibiotics, as far as Lucia Ageitos Casticirus, their peptides, are “enabled to” gram-negative pathogens, while the gram-pasted bacteria remain intact and the beneficial microorganisms of the intestine. ” “This is a rare and valuable feature Lead to the development of the most accurate and advanced antimicrobial therapy“He said more.

Spanish Caesar de La Fun, leading the investigation, these synthetic peptides have demonstrated a significant ability in premature trials, in the future, which can, which can, in the future, can “Keep the spaces the remains of the failed antibiotics“ cover ”. “By promoting ourselves in nature, we want to create effective treatment that avoid anti -problems,” said the team’s scientist at the University of Pennsylvania.

At work, bio engineering, synthetic biology and computing modeling converter, which is a new type of antimicrobial candidates. Considers the study ”An important step “safe and accurate treatments, According to scientists, it reduces the risk of promoting the appearance of new superpacteria.