Excessive consumption of fructose – common in highly treated diets – modifies the way the intestine responds to glucose, which increases the absorption of this sugar and the control of glucose in the blood. This was the conclusion of a study published in the Journal of the Malemate of the Molecular Magazine by researchers at the University of Laval (Ulaval), Canada, and the Institute of Biomedical Sciences, São Paulo University (ICB-Usp).
According to the authors, these effects that were observed in mice precede glucose intolerance and The accumulation of fat in the liverTwo factors associated with the development of type 2 diabetes and fatty liver diseases associated with metabolism (MALD). And changing bowel absorption is the problem operator.
no TicketThe mice were fed for seven weeks with a diet where 8.5 % of the energy came from fructose – a high percentage, but it is still close to human consumption. In just three days, animals have already had an increase in the intestinal capacity of absorbing glucose even before the appearance of glucose intolerance. After four weeks, glucose has no longer removed with blood efficiently, and by the end of the study, fat accumulation-a case can develop into more severe panels such as cirrhosis.
Interestingly, even with these harmful effects, the mice did not develop insulin resistance in the muscles or fatty tissues, indicating that the initial blood sugar levels occur due to changes in the intestine and not because of a mistake in the peripheral insulin response.
The interpretation of this phenomenon may be a hormone called GLP-2, which is produced by bowel cells. The researchers found that excessive fructose consumption raises the circulating LPG-2 levels, a substance that stimulates the growth of the intestinal surface and increases the absorption of nutrients. By preventing the receptors of this hormone (GLP2R) with a drug, it was possible to prevent increased glucose absorption, avoiding both tolerance and accumulation of fat in the liver.
However, the GLP2R strategy does not easily apply to humans, as this recipient himself participates in protecting the intestinal barrier from infections and infections. This enhances the complexity of the GLP-2 in metabolism health.
“We make it clear that the increase in the absorption of glycose by the intestine occurs before the glucose intolerance. This paves the way for the use of this mechanism as an early vital sign,” Fernando Fernando Favato, a professor at the Faculty of Medicine and Investigation. “The intestinal absorption test of glucose is cheap and safe and is already used in humans-it will be sufficient to apply it in a new context.”
With the support of FAPESP through four projects (20/12201-4, 22/14545-8, 20/06397-3 and 02829-1), the research was conducted by Paulo H. Evangelista-Silva, PhD in the Graduate Studies Program for Career and Surgical, at CO-UAITHIP with Eya Sellami, and shalling ATLAVAL, CA. Jordão Teixeira, a post-PhD student in the ICB-Usp.
In the next stage, with the support of the Canadian Health Research Institutes (CIHR), the group will investigate how to manipulate the intestinal microbium to reduce the harmful effects of excess fructose.
Fruit
According to Evangelist-Silva, the results of the study indicate the consumption of fructose added to Very treated foods. “Fresh fruits are rich in fiber, which helps to slow the absorption of glucose and increase satiety. In addition, they contain nutrients beneficial to the health of the intestine and the liver,” explained.
Dietary poverty for super treatment, low fibers and high levels of added sugars – such as corn syrup and sugar sugar – carry the body. Evangelist-Silva recommends giving priority to fresh foods, as a dining guide for the Brazilian population, which was developed by the Ministry of Health with the support of Pan America Health Organization (PAHO).
Sugar sugar and corn syrup are examples of the widespread fructose sugars used by industry in high -treated foods. Check some examples below:
- Industrial soft drinks and juices (up to 100 % fruit)
- Morning pills and sweetened bars
- Cookies stuffed and industrial sweets
- Bread and ready bread (such as ponds and bread)
- Ready tea and sweetened sports drinks
- Industrial sauces (ketchup, barbecue, etc.)
- Local yogurt, dairy and jam sweets
See also: Lula Veto projects equivalent to type 1 diabetes for disability
