Obtain Vaccine Rectau The same hand on the first tose According to a study led by Carwan Institute for Medical Research and The Kirbi Institute of Answ Sidney (Australia) Cell. This work provides new knowledge to help improve future vaccine techniques.
Researchers have discovered that special immune cells, known as macrophages, are manufactured within lymph nodes by managing a vaccine. These macrophages run the location of memory B lymphocytes so that Respond to the most effectively To the reinforcement toss When managed by the same hand. These innovations are made in rats and verified in human participants, providing evidence to enrich the vaccine approaches and provide a new promising approach to improve the performance of the vaccine.
“This is a basic invention How is the immune system organized To better respond to external threats: Nature has created this wonderful system. Now we have begun to understand it, ” Professor Try Fan confirms.
Professor of Science, Anthony Kelleher, Kirbi Institute and Main Co -Advocate: “A unique and elegant feature of this study is the ability of the team that understands the team Quick generation of effective vaccines. We reached this by analyzing complex biology in mice, and then we will show similar inventions among humans. All these were done where the vaccine was created: lymphatic ganglion “.
Introduces a harmless version of a pathogen, which is called Vaccine antigenIt is filtered by lymph nodes, the immune system training centers that produce the body to fight the real pathogen. Researchers had previously found it Memory B cellsIt is important to create antibody responses, and when the infections reappear, the injection is very close to the lymph node.
Using the penetrating Avant -Cart images in Carvan, the equipment invented the migration to the outer layer of the local lymph node ganglion, where they interact with the macrophages that reside there. By managing a reinforcement level in the same area, these ‘prepared’ macrophages are already cautious, They captured the antigen effectively And activated memory B cells to create high quality antibodies.
It is known that macrophages swallow pathogens and remove dead cells, but this research suggests lymph nodes Close to the place of the needle The next time they play a basic role in the orchestration with an effective vaccine. So,, The location is importantDr. Rama, the Main Co -teacher of the study conducted by the research conducted as part of his science doctorate in Karwan.
To determine the fitting of animals in animals for human vaccines, the Kirby Institute Group is a Medical Inspection with 30 Volunteers Who received the RNM vaccine COVID-19 Faiser-Payottech. Twenty participants in the first group gained reinforcement levels, and 10 were the second level in the opposite group. “Those who received both sizes in the same group created neutral antibodies against SARS-COV-2 Significantly fastIn the first week after the second toss, “Alexandra Gary-Habbe, the main co-editor and doctor of the Kirby Institute.”
“These antibodies of the same group were very useful against variations such as Delta and Omigran. In four weeks, both groups had similar antibodies, but That initial security is important during the explosion“The Main Co -author and chairman of the Kirby Institute Immunogenic Group adds to Me Ling Munior.
However, over time, research shows that the difference in safety decreases. During an infection, those first weeks may make a big difference at the security people’s level. The same hand vaccine may help help Group can reach the immune system fasterThis is very important for the fast -paced virus, where the response speed is important.
Beyond the ability to complete the vaccine guidelines, the inventions are a The way to improve performance Vaccines.
(Taxotrocelate) Health (D) Vaccines (D) immune system
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