According to a new study, the Exhibition for bacterial toxic in childhood Produced in the gut a Colonagnesis Among young people.
The results are the last evidence of what caused the global increase in early appearance. Before it was considered A disease of agingScientists rushed to understand why there were more people under the age of 50 suffering from cancer.
According to the study of 2023Number of early appearance The world has increased by 80% since 1990Deaths have increased by 28%. Prostate cancers And the nasopharynic, or associated with the throat, experienced the greatest event increase.
It is not entirely clear, but researchers believe that regeneration is a combination Environmental and lifestyle factors This stimulates mutations in our genes, increasing the risk of some kind of cancer.
New analysis, Sent to the ‘Nature’ magazine. Colobacine is made by a specific strain of the common gut microbiota, which lives in the intestine.
Exhibition in childhood It leaves a unique genetic identity on colon cellsThis increases the risk of developing colon cancer before a person 50 years of age.
Genetic changes related to colphin
“These mutation methods are a kind of historical achievement in the gene and suggests that the expression of cholebuckle in the first years of life This is the result of the deciding cause of the initial appearance of the disease“In a statement, Latmil Alexandrov, a prominent writer of the study at the University of California in San Diego, says Ladmil Alexandrov.
Researchers analyzed samples of 981 colon cancer patients from 11 countries. They found it Genetic changes attached to cholebuckin were 3.3 times more than 40 in cancer patients under the age of 40 More than those who have been diagnosed after 70 years. In countries where colon cancer is the most common of early appearance, the study found that mutations are more frequent.
In particular, as soon as the tumors have grown, genetic changes appeared quickly, indicating that according to previous investigations Mutations occur during the first 10 years of life. According to researchers, this means that bacteria may produce cancer land in young children decades ago to present symptoms.
“This changes the method of thinking about cancer,” says Alexandrov. “This is not only what happens in youth. Cancer can be affected by events that occurred in the first years of lifeMay even be in the first years. “
Limitations
Independent experts pointed it up Need more studies To confirm it Colphin -related mutations cause color cancerAs well as the way children expose to bacteria.
Trever Graham, director of the evolution and cancer center of the United Kingdom Cancer Research Institute, said, “It is not clear when and how it reaches the intestine Concrete e. coli strainWhy not usually disappear when cancer begins to grow. “
How to get rid of bacteria, there are doubts if it is It can have unnecessary effects on intestinal healthHe added that E. coli bacteria are used in some probiotics. Many more people can be revealed to colphtin, not infected with cancer, he said.
“I think that in some cases only happen, because someone can have ‘bad errors’ that causes someone to cause mutations, should be due to those errors Adequate mutations to develop cancer“Graham said.