Can be a test medicine called mahoglurund Reduce the consumption of alcohol and cocaine Among those who have this last drug consumption disorder, according to the results of a new clinical trial with 68 participants in the 2nd.
Published on Wednesday Scientific translationIt concludes A group of participants received He in general, consumed less days away from cocaine, and, in addition, showed evidence of low alcohol intake.
A treatment of pro
Results suggest that this drug should be explored, even if there are widespread and long tests Treatment for cocaine or alcohol dependenceResearchers point out.
There is Cocaine Consumption A compressive issue for public hygieneRemember a hint of the magazine, as its improper use can cause premature death, long -term health problems and social problems for consumers.
Previous investigations already showed it MGLUR5 It plays an important role in addiction and reward processing to this drug, which suggests that it can be a goal for new treatments.
And suggested that studies in animals The receptor block prevents self -regulation And the search for cocaine in rodents.
Reduces cocaine and alcohol consumption
In this phase 2 article, the researchers of the University of McGil (Canada) Baldasser Gomez-Menzilla and other centers They checked the effects of MaokulurundIt prevents MGLUR5, in addition, the study is being studied as a treatment for weak X chromosome syndrome.
During the 98 -day test, researchers administered mahoglurund or pharmacine (via oral) 68 adults aged 18 to 57 twice a day With cocaine consumption disorder.
The panel examined the changes in drug intake due to the backward self -report of the participants, as well as Analysis of urine and hair samples To detect the metabolism of cocaine.
In general The less days of cocaine will be consumed And showed evidence of shooting of low alcohol.
The drug occurred mainly Mild side effectsLike headaches and dizziness, and 76 % of participants completed the full treatment.
Limited but revealing results
Authors affiliated with Novartis for biomedical research, recognize that their results are defined by short -term The size of a small studyAlso, request additional work with a very different population to analyze the long -term effects of mahogluront on cocaine consumption.
Estephen Artis-Brado, a professor and researcher of the United States (Ecuador), and the director of the One Health Research Group, points out that it is a “well-designed and trusted” medical test, One of the greatest challenges in drug medicine: Lack of effective pharmacological treatments for cocaine consumption disorder.
The authors evaluated the MGLUR5 receiver’s selected enemy, Mawoghulunde, which “a Statistically significant reduction ” In the use of cocaine compared to the pharmacy. In addition, there was a parallel reduction of alcohol consumption, which may indicate the neurological mechanisms shared between the two products.
However, there are important limitations in the study -recognized by teachers. The model was smallMainly made up of white men and the duration of surveillance was short. “It is necessary to evaluate this drug in a very different population, including areas with high load consumption, such as Latin America.”
The results are intact, although the medical perspective is incentive Important questions that are not resolvedArtis-Brado indicates that the study does not participate.
Among them, whether their cost, if it is recognized, or can it be accessed Consumer It, often, belongs to vulnerable groups of some resources, adding to the science media center, the site of scientific resources for journalists.
The study also participated in the scientists of the Hospital Tell Mar and Clinic Hospital in Barcelona and the University of Miguel Hernandez University (Elche).
Notes
Baldasser Gomez-Manzilla et al. OvarianIn one phase 2 medical examination reduces the use of cocaine in patients with cocaine use disorder. Science Translation Medicine (2025). DOI: 10.1126/scitranslmed.adi4505
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