One of the main factors to fight Cancer It is also known that there is a good meal, but rather, there are some foods Tumor development.
Now, the Vail Cornell Medicin (USA) has been published in a premature study and magazine led by researchers Science Has revealed that products like Linoleic acid. Breast cancer ‘Triple negative’, it is difficult to treat.
Researchers found that linoleic acid can be implemented in a major growth path in tumor cells Join the protein called Fabp5.
The group noticed the implementation of this growth path when compared to breast cancer subcontinent It occurs in three negative tumor cellsFab 5 is especially abundant, but there are no other accessories that are sensitive to hormones.
In A test of mice With three negative breast cancer, linoleic acid -rich diet improved tumor growth.
“This invention helps to clarify the relationship between fats and cancer, and lights out how to define any patients from specific nutritional recommendations,” says the main author of the study physician. John BlenisProfessor of Cancer Research in the field of pharmaceutical research and a member of the Sandra Cancer Center and Edward Mayor in Weil Cornell Medicine.
Omega -6 linoleic acid is a nutrition derived from the diet, which is considered essential in mammals to support many physical processes. However, The abundance of this fat in Western foods This has been significantly increased since the 1950s, which is compatible with the largest use of seed oils in fried and ultrabrosous foods.
It has raised anxiety Excess omega -6 intake This may be one of the descriptions of the increase in rates of certain diseases, such as breast cancer. However, decades of studies have given contradictory and unfinished results, and no biological mechanism that connects omega -6 to cancer has never been discovered.
In the new study, researchers initially sought to solve this confusion that analyzed breast cancer, which is attached Changible factors such as obesity. To increase an important developmental pathway to detect nutrients through MTorc1, the efficiency of omega -6 fatty acids, especially linoleic acid, is mainly analyzed in the western diet.
A key initial discovery is that linoleic acid is actually MTORC1 active in cellular models and breast cancer animals, But only three negative sub -types.
Scientists found that this particular sub -type effect occurs Polyansicated fatty acid It creates a campus with Fabp5, which occurs at high concentrations in three negative breast tumors, but not in other accessories, which leads to the assembly and implementation of MTORC1, the main regulator of cellular metabolism and the development of cancer cells.
Feed three negative breast cancer to rats a Food rich in linoleic acid Increased Fabp5 sizes, MTorc1 activation and tumor development.
Researchers found high levels of fabp5 and linoleic acid in tumors Patient blood samples By detecting three negative cancer.
Innovations show that linoleic acid can affect breast cancer More specific context And defined what was previously believed. In addition, this common diet is believed to be the first study of the establishment of a specific mechanism that affects the disease.
In addition to finding the importance of Fabp5 in this process, it suggests that it is possible A good ‘biomarker’ For patients with three negative breast cancer, there is no currently operated treatment to guide customized nutrition and treatment interventions.
(Taxtotronslate) Health (D) Cancer
Story Credit
