A new study found that an increase in colon cancer among young people may be due to childhood infection

There is an event of colon cancer among young people Multiplied over the past twenty years Without knowing why, an international researchers have now found this increase It may be due to a bacterial infection in childhood.

The fruit of an international program, which cooperated with the University of California, San Diego, Welcome to Sanger (United Kingdom) and the International Cancer Institute of the World Health Organization (IARC), was able to reveal it. Exposure to bacterial toxic in childhood Colon cancer can trigger infection among young people. Today they publish the results of their works in the magazine Nature.

Escarichia Kohli, an old acquaintance

The work was led by the University of California and its first signature of Spanish researcher Marcos Thiaz K, who completed his doctorate at the institute after completing his doctorate. Digital Genomics Group of National Cancer Research Center (CNIO).

Colon A disease of aging.

‘Cholebuckin’ is a toxin made by some strains They expressed the coldArrow sand One of the many bacteria that expand the colon and rectumAnd the CNIO, which has the ability to replace the cells of the cells, described the toxicity in early childhood, and revealed that the discovery of a different genetic company in the DNA of colon cells.

A significant increase in related mutations

Is based on the resulting The computer analysis of genetic changesIt also proves a significant increase in the toxins in cases of colon cancer in children under the age of 50, but researchers raise questions that researchers are still unanswered, including how the infection of the bacteria produced by the colbagtin causes, and how to avoid or fight.

It has also been revealed that the research published today is firm ‘Mutual signatures‘Argentina, Brazil, Columbia, Russia and Thailand, especially in some countries’ colon cancer, may contribute to cancer, although it is not known what factors it is.

So, the Spanish researcher pointed out that it is possible Causes vary from one country to anotherThis will open the door for specific preventive strategies for each region.

One beginning in the first ten years of life

The results of this research have revealed that the harmful effects of that toxicity are beginning to begin, as the associated mutations arise in the early stages of tumor growth, which is compatible with earlier studies, which is such a Mutations occur during the first 10 years of life.

Researchers have pointed out that if someone gets one of these drivers in 10 years, it is the development of colon cancer Can advance for decadesAnd a person may be affected in 40 years instead of 60.

The impacts of this work are very relevant and scientists have highlighted because if the current trend is maintained, there may be colon cancer The main cause of cancer deaths among young people in 2030.

The reason for being founded

Young people are unknown because the cause of this increase so far Colitis They usually do not have family history and present some known risk factors such as obesity or hypertension, which has created potential causes between potential environmental cancers or microbial infections.

In fact, researchers did not focus on colon cancer of early appearance, but aimed at examining it The world forms of such cancer To understand why there are more rates than others in some countries.

But when they deepened the data, researchers check that one of the most significant inventions is the frequency Mutations related to that bacterial toxic They appeared in early appearances, thus reached the results of the newspaper today Nature.

Notes

Thiaz-K M, Dos Santos W, Moody S, Kasachkova M, Abe A, Steel C, Bankian R, Sencein S, Wang J, Fitzgerald S, Berkstrom IN, Conductor A, Otlu B, Abe-Cortegani B, Katiaz de. Fire JW, MD, LG Romanolo, DP Geological and age -related variations in mutual processes in colon cancer. Medrxiv (Preprint) (2025). DOI: 10.1101/2025.02.13.25322219.

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