Colitis The most discovered in the Spanish public populationAccording to data Spanish Association Against Cancer. According to the sources we have, Up to 80% of cases related to various environmental or lifestyle factorsUnhealthy foods, sitting lifestyle, obesity and tobacco or alcohol consumption.
Now, a new study, led by Nabil Dija Oud Dur, president of the National Cancer Research Center (CNIO) development factors, nutrients and cancer group group A new molecule instruction It can be involved in the formation of colon tumors and supports their progress towards the most aggressive forms.
An antidurmer protein that disappears
These authors are formed in an article published in a valuable education magazine Natural contactsOvarian To obtain these results, they carried out a series of research on animal models (mice) in which a certain protein, in which they noticed, Is called P53In the early stages of tumor formation, it began to decompose. They say that this will allow the appearance and growth of cancer.
Accurately, there are already other works They documented the antidumler operation of P53 protein: It is known that it prevents the segment of cells and contributes to destroying when there are dangerous contradictions, which prevents the abnormal copy of the damaged cells that can lead to tumors. Therefore, vice versa, the lower existence of B53, in a new way, has observed colon cancer, which may increase the chances of growing the cells over control.
In addition, this study has also found another interesting mechanism: The relationship between P53 and another protein called URIIt is already known for its expression (ie, by existence) in other types of tumors. In particular, the teachers noticed that URI protein levels increase the P53.
Possible method of fighting cancer
This is the first time Yuri protein is associated with colon tumors. In a statement published by the main writer Irene Herans-Montoya City“Initially the yuri sizes begin to rise too much. This leads to the formation of adenoma. It is not yet cancer, but at that point the P53 begins to decompose.”
They saw it in the tests they carried on rats Eliminate the Uri protein Or a type of premature ulcer that appears in colon tissues, raising the P53 level in polyps, which does not become tumors and rats infected with colon cancer.
“Our results are,“ proceeding with Herrans, ”contributes A comprehensive summary of how colon cancer develops. If we focus on studying the colon mechanisms that cause the degradation of the P53, including an increase in the URI, we can interfere in the early stages of cancer in the future and prevent its progress to the more aggressive forms of the disease. “So, the group now focuses on creating URI protein inhibitors.
Relationship with genetics and lifestyle
In this sense, researchers have also identified the extent of the exposure of URI protein It is controlled by a cancer It is known as MYC, which has already been identified in the control of cell proliferation and other major cancer genes. Activates the expression of the MYC URI, which stimulates the entire process described by the authors.
In addition, they say that this new mechanism may light up on some recent studies, which will investigate possible reasons Acceleration Help you understand the relationship with environmental and lifestyle factors.
“Earlier, my team also showed the expression of the uri Related to some environmental factorsAs a bad food, other types of cancer and intestines. It suggested that the degeneration of the URI and P53 at the beginning of colon cancer may be associated with these factors, ”explains J Oud Dur.
On the other hand, this progressive decrease of the P53 protein happens Independent of another process It is already known: the loss of the TP53 gene in the late stages of colon cancer (which accurately symbolizes the P53 protein). That is, both processes can cause and affect the development of parallel cancer: in the early stages, protein decay and, the loss of the gene in the most advanced or highly encroachment (and even metastases).
All these findings are verified using Raman Y Kazal Hospital Biobanco donated human samples And in conjunction with Christian Berna, adenomas and colon cancer patients in advanced theaters. They are completed with data analyzed by biomass communication methods.
Notes
AECC (2025). Colon cancer. Advice online https://www.sontracencer.es/es/todo-sobre-cancer/tipos-cancer/cancer-colon May 7, 2025.
Mount-Montoya’s Irene, Marianna-Akwado, Bernac Christian, Slotjana Jagorak, Garcia-Memanes, Solip Park & Nile Dear. The P53 protein degeneration redefines the boot mechanisms and operates interim mutations in colon cancer. Natural Communication (2025). DOI: https://doi.org/10.1038/s41467-025-59282-4
CNIO (2025). Natural contacts. He invented a molecular mechanism that starts colon cancer. Advice online https://www.cnio.es/noticias/descubierto-un-mecanismo-molocular-qu-inicia-l-cancer-de-colon/
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